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| April 27 - 29, 2006 | Washington, DC |
PROGRAM SCHEDULE
Thursday, April 27
Friday, April 28
Saturday, April 29
Click here to download a printable version of the schedule with complete schedule times
Thursday, April 27
| 12:00 - 12:10 pm | Welcome
Philip C. Fox, DDS
Symposium Chair
SSF Board Chair and President
Steven Taylor
CEO, Sjögren's Syndrome Foundation |
| 12:10 - 12:20 pm | The International Symposia Research Highlights from the VIIIth International Symposium in Japan
Susumu Sugai, MD
Japan |
I. Etiopathogenesis Part I — Genetics
12:20 - 2:05 pm |
| Moderator: | Roland Jonsson, DMD, PhD
Norway |
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Overview — What do we know now, and what candidate genes are investigators examining?
Anne Bolstad, PhD
Norway |
Etiology, genetics, and environment — Lessons for Sjögren's from Lupus
John Harley, MD, PhD
Oklahoma |
Gene expressions that appear in multiple autoimmune disorders
Kathy Moser, PhD
University of Minnesota |
| Panel Discussion: Similarities and Differences between Primary Sjögren's, secondary Sjögren's, and related autoimmune disorders |
II. Etiopathogenesis Part II
2:25 - 6:00 pm |
| Moderator: | Antony Rosen, MD
Johns Hopkins University |
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Functional antibodies
Tom Gordon, MD, PhD, FACR
Australia |
Apoptosis
Mary Reyland, PhD
University of Colorado |
Salivary Gland Pathophysiology
Luke Dawson, BSc, BDS, PhD
Great Britain |
Altered Ocular Surface System Mucosal Immune Regulation in Sjögren's Etiopathogenesis
Austin Mircheff, PhD
University of Southern California |
| 4:10 - 4:35 pm: Break |
| 4:35 pm: Session II resumes |
Cytokines and inflammatory mediators
Gabor Illei, MD, PhD, MHS
NIDCR, NIH |
TNF superfamily/BAFF/BlyS
Susan Kalled, PhD
Cambridge, MA |
Viruses
Harry Moutsopoulos, MD, FCP, FRCP
Greece |
| Wrap-up |
| WELCOME RECEPTION IMMEDIATELY FOLLOWING PROGRAM
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Friday, April 28
| 8:00 - 8:05 am | Welcome and Overview
Philip C. Fox, DDS
Symposium Chair |
III. Research Updates — Sharing Conclusions from Recent Gatherings and Discussing Future Directions
8:05 - 10:30 am |
| Moderator: | Philip C. Fox, DDS
Symposium Chair |
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Transition from Autoimmunity to Lymphoma
Recommendations from the September 2005 workshop, Sjögren's Syndrome: Transition from Autoimmunity to Lymphoma
Elaine Alexander, MD, PhD
Sjögren's Syndrome Foundation Workshop PI |
International Sjögren's Syndrome Registry and Repository:
A Major Resource for Researchers — Preliminary Findings
Troy Daniels, DDS, MS
University of California, San Francisco
Registry PI
John S. Greenspan, BDS, PhD
University of California, San Francisco
Registry PI |
International Sjögren's Syndrome Registry and Repository:
Discussion: A panel discussion with participating international research groups and directors
Moderator: Troy Daniels, DDS, MS
University of California, San FranciscoPanel:- Yi Dong, MD
China - Hector Lanfranchi, DDS, PhD
Argentina - Morton Schiødt, DDS
Denmark - Susumu Sugai, MD
Japan |
New Data on Outcome Measures
Update from the workshop, Outcome Measures for Sjögren's Syndrome (Bethesda 04/2003)
Simon Bowman, PhD, FRCP
Great Britain |
Italian Multicenter Collaboration on Activity and Damage Indexes
Claudio Vitali, MD
Italy |
Changing perspectives in the definition and diagnosis of dry eye:
Update from DEWS (Dry Eye Workshop International)
Michael Lemp, MD
Georgetown and George Washington University |
| Q&A on Research Updates |
IV. In Search of a Better Animal Model
10:45 am - 12:30 pm |
| Moderator: | Hal Scofield, PhD
Oklahoma |
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Moving beyond the NOD mouse
Ammon Peck, PhD
University of Florida, Gainesville |
NFS/sld
Yoshio Hayashi, MD
Japan |
60 kD Ro-induced BALB/c mice
Biji Kurien, PhD
Oklahoma |
NOD-H-2h4 mice
Lynne Burek, PhD
Johns Hopkins University |
| Space left for interesting abstract |
| Discussion: What can we learn from traditional models for Sjögren's and from those used for other autoimmune disorders? (include Id3 KO) |
V. Posters and Poster Discussion — Session I
1:30 - 2:45 pm |
| Moderator: | Arjan Vissink, MD, DDS, PhD
The Netherlands |
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VI. Clinical Manifestations — New Findings
2:45 - 5:25 pm |
| Moderator: | Ann Parke, MD
University of Connecticut |
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Rheumatic/systemic
(including fatigue and QOL)
Elke Theander, MD, PhD
Sweden |
Ocular
Talk #1
Stephen Pflugfelder, MD
Baylor College of Medicine
Talk #2
Space saved for an interesting abstract |
Oral
Talk #1
Anne Marie Lynge Pedersen, DDS, PhD
Copenhagen
Talk #2
Space saved for an interesting abstract |
Parasympathetic dysfunction and urological symptoms
Maureen Rischmueller, MD
Australia |
Risk factors for mortality
Athanosius Tzioufas, MD
Greece |
| Wrap-up |
| 6:45 pm | Buses Start to Depart for Moonlight Dinner Cruise on the Potomac River |
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Saturday, April 29
| 8:00 - 8:05 am | Welcome and Overview
Philip C. Fox, DDS
Symposium Chair |
VII. Point/Counterpoint:
"Is Sjögren's syndrome a T- or B-cell disease?"
8:05 - 9:00 am |
| Moderator: | Thomas Dörner, MD
Germany |
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Arguments for Sjögren's as a T-cell disease
Phil Cohen, MD
Univeristy of Pennsylvania |
Arguments for Sjögren's as a B-cell disease
Pierre Youinou, MD, PhD
France |
| Discussion |
VIII. Why does Sjögren's syndrome primarily affect women?
9:00 - 9:55 am |
| Moderator: | David Sullivan, PhD
Schepens Eye Research Institute |
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The female proclivity toward autoimmunity and sex-associated differences in susceptibility
Caroline Whitacre, PhD
Ohio State University |
Sex hormones as modulators and perpetuators of autoimmune disease; Endocrine-immune reactions
Maurizio Cutolo, MD
Italy |
| Discussion |
IX. Novel Therapeutics I
10:25 am - NOON |
| Moderator: | Gary Foulks, MD, FACS
University of Louisville |
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Targeted tear film therapy and local therapeutics (including cyclosporine)
Janine Smith, MD
National Eye Institute, NIH |
Secretogogues
Frederick Vivino, MD, FACR
University of Pennsylvania |
Cytokine-directed therapeutics
Peter Szodoray, MD
Hungary and Norway |
| Hold open for late-breaking topic |
X. Posters and Poster Discussion — Session II
1:00 - 2:15 pm |
| Moderator: | Athena Papas, DMD, PhD
Tufts School of Dental Medicine |
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XI. Novel Therapeutics II
2:15 - 4:45 pm |
| Moderator: | Xavier Mariette, MD
France |
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T cell-directed
Randall Q. Cron, MD, PhD
University of Pennsylvania |
B cell-directed
William St. Clair, MD
Duke |
| Discussion: Why would certain immunomodulators (including monoclonals and anti-TNF) benefit some autoimmune disorders but cause serious side effects in Sjögren's? |
Stem cells and repair in autoimmunity
Antony Rosen, MD
Johns Hopkins University |
Regeneration of damaged cells
Denise Faustman, MD, PhD
Harvard University |
Gene therapeutics
Bruce Baum, DMD, PhD
NIDCR, NIH |
| 4:45 - 5:00 pm | Closing Remarks
Philip C. Fox, DDS
Symposium Chair
SSF Board Chair and President |
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